Actos Injury Info (2/8/12): The diabetes medication Actos has caused some individuals harm through an Actos Injury. The FDA has an active safety alert regarding a possible Actos Injury risk to the public. According to the FDA, the side effects related to Actos Injury can be significant. As a result, a number of Actos Injury lawsuits are being pursued nationwide. If you took Actos and were later diagnosed with an Actos Injury, contact Best Legal Source today at (800)-611-7080 and we’ll put you in touch with an Actos Injury lawyer concerning your potential Actos Injury lawsuit. You can also contact Best Legal Source by completing the form to your right.
Specifically, Actos has a boxed warning that it may cause or exacerbate heart failure. Another possible Actos Injury was issued by the FDA through several safety communications linking Actos to increasing the risk for bladder cancer in consumers who have had two years of exposure. An Actos Injury can be treated although in some cases an Actos Injury can create life-threatening conditions.
An Actos Injury should be taken seriously due to the conditions it may create that pose a challenge to your quality of life. Please consider calling an Actos Injury lawyer to learn more about the possible Actos Injury lawsuit.
Actos Injury, Actos Injury Lawsuit and Actos Injury lawyer are terms we use descriptively. The term Actos Injury is not meant to imply that Best Legal Source is the maker of Actos. Actos Injury is a term used to describe bladder cancer, cardiovascular problems and other health conditions caused by Actos side effects.
It is the intent of Best Legal Source to assist people who have had an Actos Injury because of the side effects of defective drugs like Actos to find quality legal representation. Our services are free to the public. If you took Actos and later developed an Actos Injury, please contact Best Legal Source through our toll-free number today so we can arrange a meeting with an Actos Injury lawyer.
Disclaimer: The information provided by this website is not legal advice. Best Legal Source is not a law firm. No confidential relationship and or attorney-client relationship is formed by use of the site. Best Legal Source does not recommend or endorse any particular lawyer or their qualifications. This site is sponsored by attorneys who may receive leads from Best Legal Source. Best Legal Source does not make attorney referrals. The mission of Best legal Source is to assist injured partied in locating an attorney that is willing to review and potentially accept the injured parties legal case.
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Please contact us today if you took Actos Injury and suffered unusual side effects or other injuries.
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Actos Injury: Cancer cells can spread throughout the body. They can spread through the lymphatic system, composed of lymph channels and lymph nodes, or distantly to other organs or the skeleton via the blood stream (hematogenous spread). In the case of bladder cancer, the cells can also spread by being carried in the urine and implanting in other locations in the urinary tract.
The pathologist studies the prepared slides and makes a determination of the grade of cancer. There are a number of criterions that are used: degree of cellularity, nuclear crowding, loss of polarity and differentiation, nuclear pleomorphism, chromatin pattern and mitotic activity. In layman’s terms, the pathologist looks at the size, shape and relationship of the cancer cells. The nucleus is often abnormal since it contains damaged or mutated DNA. Cancer cells look different than normal cells. The greater the difference from normal, the higher the grade will be. These parameters are utilized to reduce the subjective nature of pathology.
If a urine dipstick is positive for blood, it is recommended to check the urine under a microscope. The urine is first spun down to separate out the sediment and is then examined under the high power lens. If there are more than 3 red blood cells per high power field it is felt to be significant. If there are no other reasons for the presence of blood such as a urinary infection, the urine should be rechecked. If there is a persistent presence of significant microscopic hematuria, an assessment is recommended. When there is a large amount of microscopic hematuria, especially in older individuals with risk factors for bladder cancer, there is no need to repeat the urinalysis as a workup should be done.
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Actos Injury: Cystoscopy (examination of the bladder) is usually the first step in making the diagnosis of bladder cancer. Given the signs and symptoms suggesting bladder cancer, or an X ray or ultrasound revealing a possible bladder tumor, cystoscopy is a must. Cystoscopy can be accomplished with either a flexible cystoscope or a rigid scope. The flexible cystoscope is composed of small optical fibers encased by a plastic sheath. A rigid scope has glass lenses within a metal sheath. Both cystoscopes are passed directly through the urethra into the bladder to visualize the inside surface. Cystoscopy can be accomplished in both the urologist’s office or as an outpatient at a hospital or surgicenter.
The flexible cystoscope is easier and less painful to pass, especially for males whose urethra is longer and more tortuous than in females. Flexible cystoscopy is readily accomplished in the doctor’s office. A lubricant is applied to the scope to ease passage. Local anesthesia can be squirted into the urethra prior to passing the scope. Discomfort from the cystoscope is usually well tolerated and short in duration. The discomfort usually lasts a few seconds as the scope is passed through the prostate. At that time, you may feel a pressure sensation. In females, passage of the scope is quick and relatively painless.
If you are being initially screened for asymptomatic microscopic hematuria, a urologist will often choose flexible cystoscopy as the first step. He is not certain whether or not you have a bladder cancer or other condition causing the hematuria. Flexible cystoscopy will provide that answer in a less time consuming, less painful and more cost effective way than rigid cystoscopy. On the other hand, if there is a high likelihood a tumor is present, it makes sense to do rigid cystoscopy and if required, resection all at one setting.
Because a positive cytology is very specific for cancer, it is highly predictive of transitional cell cancer even if no tumor is visible during cystoscopy. Additional information can be obtained with urine cytology. The DNA content and measurement of the amount of abnormal DNA can be determined. In general, as the amount of abnormal DNA is increased, the prognosis is worsened.
When an individual has gross hematuria or persistent microscopic hematuria, a complete assessment of the urinary tract is required. Although cystoscopy is the test of choice for examination of the bladder, imaging studies are required to make sure there is no disease in the upper tracts (kidneys and ureters). Bleeding can be caused from many different disorders including transitional cell carcinoma of the upper tracts, kidney or ureteral stones, or renal cell carcinoma (cancer of the parenchyma or fleshy part of the kidneys). Your urologist has a number of options to choose from. There are advantages and disadvantages of each.
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Actos Injury: CT Scan or CAT (computerized axial tomography) provides a computerized cross sectional visualization of the abdomen and pelvis. X ray images are synthesized into exquisitely detailed images. The CT scan can be done with or without IV contrast, and therefore has the same limitations as IVP in those with allergies to contrast or renal insufficiency. These studies are excellent for finding renal cell cancers and stones within the kidneys and ureter, but not very good at delineating cancers of the lining. CT scan is often an important part of staging bladder cancer, determining whether the cancer has spread.
Magnetic Resonance Imaging (MRI) is a technology which uses strong magnets to provide detailed images of your internal organs. Like ultrasound, this study has no known harmful effects on the body. It does not require contrast injection like CT scan and can be done safely in patients with renal insufficiency. It is not generally used for initial screening. Many individuals find the test uncomfortable due to a loud noise heard throughout the test, in addition to the close quarters the machine requires, leading to feelings of claustrophobia.
Initial treatment may eradicate an individual’s bladder cancer, however, for many, recurrent tumors may develop. Up to 70% of individuals will have recurrent bladder cancer after initial therapy. In approximately one third of patients, not only will tumors recur, but they will become more serious over time, developing a higher grade or stage. This chapter will review the importance of staging bladder cancer, the single most important predictor of future problems. In addition, we will review other important indicators that impact the prognosis.
In the case of bladder cancer, initial stage is critical in predicting the prognosis. For individuals with bladder cancer, recurrence (repeated tumors) is common. For many, progression (the development of higher grade, invasive or metastatic cancer) is also a real concern. By looking at the initial stage of the bladder cancer and restaging with each new cancer recurrence, the urologist can predict or prognosticate the possibility of the individual developing more life threatening invasive disease which has the ability to spread beyond the bladder and lead to death. Treatment options exist at each stage of cancer. It is the goal of the urologist to preserve your bladder as long as possible without jeopardizing your life with a cancer that may spread and become incurable.
Actos Injury: Information and News
Actos Injury: Most individuals with bladder cancer will undergo an initial removal of their bladder tumor by biopsy or for larger tumors by resection of their tumor via a resectoscope. For complete details see Chapter 8. Once this tumor is removed, the pathologist will determine and report on the extent of tumor invasion into the wall of the bladder. If the tumor has grown into the prostate, tissue removal via the resectoscope from this location will also be reviewed and reported pathologically. This pathologic diagnosis determines the initial stage of the cancer.
Once an individual develops bladder cancer, there is a high likelihood that even after removal of the cancer, recurrence will occur. Depending on the initial presentation, some 60-90% will at some time experience recurrent disease. Due to the high recurrence rate, bladder cancer is the second most prevalent cancer in middle aged and elderly men. Recurrence requires repeated endeavors at tumor removal and the possibility of adding other treatment regimens, which can be time consuming, costly and emotionally and physically challenging.
In some individuals recurrence is also accompanied by progres¬sion, the development of higher grade, invasive bladder cancer with the propensity to spread and possibly take the life of the individual. For many individuals with low stage, low grade disease, recurrences may be minimal and progression almost nil. For those with more intermediate grade and stage, there exists a higher recurrence and progression rate.
Carcinoma in situ (CIS or Tis): although these “flat” tumors are confined to the most superficial layer, they are generally multi¬focal, high grade and have a high likelihood of invasion with a substantial risk for cancer death. They may appear as red velvety or granular areas, or may not be visible through the cystoscope, but are found on random biopsy. CIS will usually result in an abnormal cytology. If an individual has diffuse CIS with irritative symptoms, progression to invasive disease can be expected in up to 80%. For those with only focal CIS, without symptoms, progression occurs in less than 10%. In a recent series from the Mayo Clinic, the rate of progression per year was 4% . When CIS is associated with even low grade, early stage bladder cancers, progression is seen in over 80%, similar to those with diffuse, symptomatic CIS. When CIS is found in conjunction with superficial bladder cancer, the prognosis is markedly worsened.
Our use of the term or terms Actos Injury is for descriptive purposes only. There is no relationship between the owners of this website and the maker of the product discussed in this post. Our use of the words Recall, Class Action Lawsuit and other similar words related to an event do not necessarily mean that this event has occurred. Refer to the website of the United States Food and Drug Administration for information on drug or medical device recalls. If a Class Action Lawsuit is formed in relation to the product discussed in this post we will provide that information at the time the Class Action is formed. A Class Action Lawsuit is not required to exist for you to file a lawsuit if you have been injured by the product discussed in this post.
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